Effect of centchroman on lipid metabolism in genital organs of female rhesus monkeys (macaca mulatta)

K. Nigam, Prabhat and R. Chowdhury, Sunil and P. Kamboj, Ved and Chandra, Harish (1987) Effect of centchroman on lipid metabolism in genital organs of female rhesus monkeys (macaca mulatta). Malaysian Journal of Reproductive Health, 5 (1). pp. 37-45. ISSN 0217-3213

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Abstract

Effect of Centchroman (3,4-trans-2, 2-dimenthyl-3-phenyl-4-p (B-pyrrolidinoethoxy)-phenyl-7-methoxy chroman)treatment at 1 and 2.5 mg/kg; for 3, 6 and 12 months on lipids constituents of uterus,cervix and vagina was studied. Centchroman did not cause any consistent pattern of alteration in lipid contents of uterus, cervix and vagina of female rhesus monkey. However, uterine phospholipids were decreased at both the doses and cervical and vaginal triglycerides increases at higher dose. The altered nature of responses in the genital organs may be due to manifestation of estrogenic-cum-antiestrogenic properties of centchroman.

Item Type: Article
Keywords: early embryonic development, endogenous hormones, lipid constituents
Subjects: 600 Technology > 610 Medicine & health > 618 Gynecology, obstetrics, pediatrics & geriatrics
Division/Agency/State: LPPKN - National Population and Family Development Board, Malaysia > Division of Reproductive Health
Deposited By: Mrs Noor Azreena Abd Aziz
Deposited On: 29 Apr 2015 02:36
Last Modified: 06 Feb 2017 04:21
URI: http://familyrepository.lppkn.gov.my/id/eprint/514

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