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Results for Search : "610 Medicine & health"

2023 (2)




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Enhancing Pregnancy Outcomes in Women with Polycystic Ovary Syndrome
Item Type: Research Report
Author: 
Lembaga Penduduk dan Pembangunan Keluarga Negara, Malaysia.,  and
Author: 
Editor: 
Year:  00/01/2023
Abstract:  Polycystic ovary syndrome or known as polycystic ovarian syndrome (PCOS) is an endocrine disorder and one of the main causes of anovulatory infertility in women of reproductive age, which is 15 to 49 years (Balen et al., 2016). The main characteristics of women with PCOS are ovarian dysfunction, hyperandrogenism and polycystic ovaries (Balen and Michelmore., 2002). This syndrome is associated with metabolic syndromes such as obesity, insulin resistance, diabetes mellitus type 1 (Barthemess and Naz., 2014) and arteriosclerosis (Orio et al., 2004). The general objective of this study is to identify the demographic characteristics, clinical and medical history, of PCOS sufferers as well as appropriate treatment methods among clients seeking fertility treatment at the LPPKN Subfertility Clinic. This study is an experimental, case control study involving female clients who come to seek fertility treatment at the LPPKN Subfertility Clinic. The chosen location is LPPKN Headquarters, Kuala Lumpur. Every female client who attends needs to meet the patient selection criteria, namely a Malaysian couple, trying to conceive for more than a year and aged between 25 to 38 years old. Every patient who faces subfertility problem is divided into two groups, namely PCOS and no PCOS. Patients who are eligible and agree to participate in the study have gone through at least five (5) series of appointments with medical officers and nurses. A total of 167 patients participated in this study with an average age of 30 years.
 
 
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2022 (2)




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Statistik data perkhidmatan perancang keluarga LPPKN tahun 2015-2019
Item Type: Report
Author: 
Lembaga Penduduk dan Pembangunan Keluarga Negara, Malaysia,  and
Author: 
Editor: 
Year:  00/00/2022
Abstract:  National Population and Family Development Board Malaysia (NPFDB) have prepared a statistic report on family planning services at the NPFDB level according to the number of new recipients, type of contraceptive, state, age group, ethnicity, strata and employment status for 2015 to 2019. This report only consist new recipients, which is new clients who have not registered with any of family planning agency such as NPFDB, Ministry of Health (MOH), Malaysian Armed Forces (ATM) and Federation of Reproductive Health Associations Malaysia (FRHAM). The breakdown of statistic report by type of contraceptive have included implant, injection, condom, pill, intrauterine device and non-modern methods. Meanwhile, the breakdown of family planning data by age have covered the range of 15 years to 49 years. The breakdown of data by ethnicity also have included Malay, Chinese, Indian, other bumiputera and other ethnicities. These statistic data were also have provided by strata (urban and rural), employment status (employed and unemployed) and education breakdown including college/ university, secondary school, primary school and non formal education.
 
 
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2021 (3)




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Development of a high-energy nutrient-dense meal as supplementary functional food for improving problem of stunted and under-nourished children
Item Type: Article
Author: 
Muhamad, Isa Idayu and
Abang Zaidel, Dayang Norulfairuz and
Mohd Jusoh, Yanti Maslina and
Pa'e, Norhayati and
Khair, Zulkifli and
Abdul Majid, Hairudin and
Author: 
Editor: 
Year:  00/12/2021
Abstract:  Poverty, obesity and lifestyles are the most associated factors of vitamin D deficiency among urban-living children in Malaysia. Vitamin D is necessary for calcium absorption from food to ensure healthy bones and teeth. Vitamin D deficiency can cause soft and brittle bones disease known as rickets in children and osteomalacia in adults. Based on previous research, lack of nutritional knowledge among parents can contribute to nutrition deficiencies in children. To overcome this issue, nutritional education and awareness campaign among parents are needed. Besides campaign, the development of supplementary functional food which can provide crucial nutrients and energy that can assist in brain and body growth seems beneficial.
 
 
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Family well being & the emergence of global pandemic
Item Type: Newsletter
Author: 
Author: 
Editor: 
Mahpul, Irwan Nadzif and
Mohammad, Ahmad Hashimi and
Mazalan, Mohd Firdaus and
Abdul Razak, Ahmad Rasyidee and
Mohammad Fuzi, Nur Ashikin and
Sukarno, Nur Syafira and
Year:  00/00/2021
Abstract:  National Population and Family Development Board (NPFDB) has introduced a Family Well-Being Index (FWBI) to specifically measure the well-being of families in Malaysia. The third series of the FWBI was conducted in 2019, prior to pandemic which start hitting the globe at the end of year. The FWBI 2019 reached a new highest score of 7.72 out of a maximum scale of 10. Although the FWBI 2019 score is still at a moderate level, it has shown an increase of 0.39 points compared to previous 7.33 for FWBI 2016. The FWBI 2019 score is a reflection of the family well-being in the country before COVID-19 pandemic began. Since then, every aspect of our life have been aff¬ected and subsequently transform the way we work and doing things. In addition to hampering the economy, the pandemic has also impacting family institution as a whole.
 
 
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2020 (6)




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Seroprevalence and factors associated with chlamydia trachomatis Infection among subfertile couples attending local public subfertility clinic
Item Type: Thesis
Author: 
Nekmat, Nily waheeda and
Author: 
Editor: 
Year:  00/00/2020
Abstract:  Chlamydia trachomatis is one of the agents that cause the sexually transmitted infections called chlamydia. People practicing risky sexual behaviours such as having multiple sex partners, exercising sexual intercourse at an early age, and undergoing unprotected sexual intercourse (without condom) with casual partners, are at risk of getting Chlamydia trachomatis infection. One of the significant, long term implications of risky sexual behaviours and sexually transmitted infection is infertility problems. The objectives of this study are to determine the seroprevalence of Chlamydia trachomatis (CT) among subfertile couples (husband and wife) of The Lembaga Penduduk dan Pembangunan Keluarga Negara (LPPKN) Subfertility Clinic and the factors associated with it (i.e. socio-demographic, duration of marriage, infertility factor, knowledge, attitude, practice of risky sexual behaviour (RSB) and predictors of Chlamydia trachomatis infection). The study is a cross-sectional study involving 112 infertile couples who underwent fertility treatment at LPPKN Subfertility Clinic from February 2018 until February 2019. Sociodemographic factors, duration of marriage, infertility factor, knowledge, attitude and practice (KAP) of risky sexual behavior (RSB) variables were determined via self-administered questionnaire that includes close ended questions. Meanwhile, Chlamydia trachomatis antigen and antibody (CT IgG) were determined via Enzyme Linked Immunosorbent Assay (ELISA) and rapid visual immunoassay test kit. This approach is selected to detect past and current infections of Chlamydia trachomatis through antibody and antigen detection in the blood serum, endocervical swab and urine samples. The response rate of this study was 97.39%. Majority of the respondents were aged between 25-34 years old and dominated by Malay ethnicity. Half of the respondents were among those with tertiary level of education and working in the private sector. In term of duration of marriage, half of the samples were couples who have been married for 3-7 years with majority of them had primary infertility. The female factor was reported to be the most dominant, followed by the unexplained factor and male factor. The seroprevalence of Chlamydia trachomatis among subfertile couples was 22.1% with 14.7% in husbands and 17.9 %, was reported among wives. In terms of knowledge, the results showed that most couples had high level of knowledge about risky sexual behaviours with a score of more than the mean (> 6) for both husbands and wives. Meanwhile, each husband and wife group had positive attitude towards risky sexual behavior. Approximately, 35.7% of husbands and 12.5% of wives were engaged with risky sexual behavior while a higher percentage of premarital sex was reported among the husbands compared to the wives. The chi-square results showed no association between CT status and socio -demographic factors, marital status and knowledge of RSB among subfertile couples. A significant association was recorded between CT and practices of RSB among couples (p< 0.05) particularly among those with multiple sex partners and husbands who had premarital sex (p<0.05). However, the Binary Logistic Regression analysis showed that none of the selected variables were significant predictors of CT status among the couples (p> 0.05). This study has determined that the seroprevalence of Chlamydia trachomatis (22.1%) and practices of risky sexual behavior among subfertile couples were high. Even though the results have shown no association between the dependent and independent variables, our finding has given an evidence based detection of past infection of Chlamydia trachomatis among subfertile couples. The practice of RSB has interrelated risk of getting CT and its long term consequences particularly on women reproductive system. Since the awareness on CT among public is considered low, it is crucial to sensitize them about it to ensure early detection and prevention. Therefore, CT screening is strongly recommended to be integrated in fertility work up. treatment and be promoted among sexually active adolescents and those young in age.
 
 
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2018 (2)


2017 (4)




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Effects of socio-demographic, lifestyle and environmental factors on semen quality of men attending the sub fertility clinic in National Population and Family Development Board
Item Type: Research Report
Author: 
National Population and Family Development Board, Malaysia,  and
Author: 
Editor: 
Year:  02/01/2017
Abstract:  Couples are considered infertile if they are unable to conceive after one year of regular unprotected sex. The impact of lifestyle and environment on human fertility may vary depending on aetiology, demographic characteristics, genetic variation and other factors. As used by previous researchers, semen parameters were used to measure male infertility. Therefore, a decrease in semen quality is considered as a major factor in male infertility (http://en.wikipedia.org/wiki/Semen_quality). Previous studies (Kidd et al.2001,Eskenazi et al.2003, de La Rochebrochard and Thonneau 2003) have found that older men tend to have lower semen quality than younger ones. Testicular hyperthermia (elevated temperature) also has been known to affect male fertility. Men who like taking hot baths or sit in a sedentary position for a long time are at risk of having infertility. The objectives of this study are to identify the relationship between socio-demographic profile, lifestyle and environmental factors and semen quality, and to identify risk factors of poor semen quality among men attending the National Population and Family Development Board's (NPFDB) Subfertility Clinic. This study was done in Andrology Laboratory, NPFDB. Five hundred men from couples having their first infertility consultation between September 2010 abd June 2011 were recruited. Each patient was required to register, deposit semen and fill in the quesstionnaire. Sperm concentration, morphology and motility from semen analysis were used to study the relationship between semen quality and independent variables. Reference limits used were 15 cells x 10'6/ml, 4% and 40 %, respectively (World Health Organization, 2010). For statistical analysis, descriptive statistic, t test and ANOVA were used; 0.05 alpha value was chosen. Results showed that one-third of the study population were between 26 to 30 years of age and another one third were aged between 31 to 35 years old; mean age was 33.2. majority were Malays (71.2%), resided in Selangor (64.3%) and professionals (41.6%). Semen quality showed a negative relationship (p<0.05) with age. Meanwhile, sperm motility varied significantly for different ethnic group. Chinese (57.75%) had the highest motile-sperm compared to Malays (53.44%) and Indians (46.60%). Among lifestyles variables, frequency of sexual intercourse had a posive relationship (p<0.05) with sperm motility, whilst sedentary position had negative relationship (p<0.05) with the latter. Regression analysis was used to predict the risk factors of poor semen quality. This study found that men above 30 years old were two times more likely to have low sperm motility than men in the twenties. Moreover, less frequent sexual activity between couples was more likely (p<0.05) to have abnormal sperm compared to those who had sexual intercourse more frequently. In conclusion, this study suggested that age over 30 years and infrequent sexual activity were the risk factors to lower semen quality. Even though not regarded as a risk factor, sedentary work position had a negative impact on sperm motility. These factors may affect male fertility and cause difficulty in conception. Public awareness through advocacy programs and talks on infertility and its risk factors should be carried out regularly. Public education should be carried out to advice men to practice a healthy lifestyle and work life balance. This study has shown encouraging results, and should be replicated in the general population in Malaysia
 
 
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2016 (3)




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Kajian bagi mengenalpasti faktor-faktor risiko kanser payudara yang berkaitan dengan gaya hidup dalam kalangan wanita melayu di Kuala Lumpur
Item Type: Thesis
Author: 
Affandi, Khuzailah and
Author: 
Editor: 
Year:  00/02/2016
Abstract:  Breast cancer is the most common cancer that has affected women all over the world. The worldwide rates of breast cancer incidence and mortality show a drastic and alarming increase. Until today the cause of the disease has yet to be identified. However, evidences from extensive researches related to breast cancer found that there were several lifestyle factors and some biomedical factors of the women that are scientifically recognized to increase the risk for breast cancer. In Malaysia, recent data obtained from data obtained from the National Population and Family Development Board (NPFDB) shows the incidence rate of breast cancer among Malay women was found to have increased drastically in the last 8 years. This study aimed to identify risk factors, especially those related to lifestyle that may increase the risk of breast cancer among Malay women in Kuala Lumpur. The study also examined the knowledge of breast cancer among informants. A total of twelve breast cancer survivors were interviewed in depth to identify and explore aspects of past lifestyle and biomedical background that may likely to increase their risk of getting breast cancer. Results show that some lifestyle and biological risk factors seen likely to increase the risk of getting breast cancer; late age at first birth or has never given birth (nulliparity), has never breastfed or short period of breastfed, obesity, physical inactivity, high frequency of red meat intake, less intake of vegetables and fruits, psychological stress, family history of breast cancer and radiation treatment to the chest or breast. The study also found that the majority of the informants had poor knowledge regarding breast cancer.
 
 
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2015 (3)


2012 (5)




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Predictor of successful Intra Uterine Insemination (IUI) treatment for infertile couples treated at a Malaysian clinic
Item Type: Conference or Workshop Item
Author: 
Ismail, Maslinor and
Author: 
Editor: 
Year:  00/00/2012
Abstract:  The purpose of the study was to determine prognostic factors that affect the success rate of Intrauterine Insemination (IUI) as well as association of prognostic factors with success rate of IUI treatment for infertile couples. A retrospective cohort study investigating the prognostic factors affecting success of IUI was done at National Infertility clinic. A total of 1585 couples involving 3249 IUI cycles with ovarian stimulation using clomiphene citrate and/or human menopausal gonadotrophin (HMG) were recruited from lst January 2000 till 3lst December 2006. The pregnancy rate per cycle and per couple was 3.7% and 7.4%, respectively. Logistic regression analysis had determined three prognostic variables as regards pregnancy namely as duration of infertility a = 0.002), interval of menstrual cycle a = 0.00025) and sperm count a = 0.016). The percentage of women successfully pregnant after cycle one till cycle 5 IUI were ranging from 3.4% to 4.8%. Results showed that no pregnancy occurred after the sixth cycle of IUI. The result suggests that duration of infertility is of utmost important determinants of an infertile couple in view of IUI success rate.
 
 
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Kontraseptif kecemasan: kesedaran dan penggunaannya
Item Type: Conference or Workshop Item
Author: 
Shekh Abdullah, Faezah and
Author: 
Editor: 
Year:  00/00/2012
Abstract:  Emergency contraceptive (EC) is one of the methods of contraception used after unprotected sex. With proper use, this method of emergency contraception can help reduce the problems of unplanned or unwanted pregnancies that have been frequent in recent times. The objective of this study was to identify women’s awareness of emergency contraceptive methods and their level of use. The research method involved the distribution of questionnaires to 1000 women, aged 15 to 49 years, who attended programs organized by NPFDB. Data collection and analysis was carried out using SPSS 11.5 software. The chi -square test was used to study the relationship between the sociodemographics of the respondents and the variables studied. The coverage of the study consisted of 84% Malay women, and was followed by Indians (9%) and Chinese (6%). The majority of respondents (43%) were in the range of 25 to 34 years, with a mean age of 33 years. Contraceptive use among respondents was found to be 26.3%, of which 98% were married women. The study found that women’s awareness of EC and its level of use was low, being only 29% and 3.9%, respectively. The chi -square test results showed that the level of awareness of EC increased with age (p <0.05). In addition, more highly educated women were found to have heard of EC (p <0.05) compared to low levels. Most EC users are from the married group. Nearly 70% of women who are using contraceptives are found to have used EC. Among women who have never used EC, only 21% are interested in using it in the future. However, the majority (70%) support this service provided at NPFDB. The lack of exposure on EC results in the number of women interested in using it being low. Therefore, NPFDB and related parties need to enhance promotional activities, advocacy and learning of emergency contraceptive methods, in addition to other methods, so that the community knows about it and can use it during emergencies.
 
 
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National experience in population matters: adolescents and youth
Item Type: Newsletter
Author: 
Author: 
Editor: 
Ismail, Siti Norlasiah and
Mahmud, Adzmel and
Muda, Rozi and
Ishak, Ismahalil and
Mazalan, Mohd. Firdaus and
Abdullah Daud, Noor Azizan and
Abdul Hamid, Azian and
Year:  00/00/2012
Abstract:  Adequate and accurate sexual and reproductive health information helps young people to make informed and responsible decisions. Howewer, cultural and religious sensitivities within the communities remain one of the major challenges in implementing reproductive health education for young people. Parents are still uncomfortable talking about reproductive health matters with their children ,leaving their children dependent upon information from their peers or other sources like the internet. The Government of Malaysia takes cognisance of the increasing importance of the sexual and reproductive health needs of adolescents and youth in Malaysia. Hence, the Government of Malaysia has put in place various policies and programmes to handle the sexual and reproductive health needs of the adolescents and youths. One of the main initiatives is the Healthy Programme without AIDS for Youth (PROSTAR). The Government of Malaysia also has established six youth-friendly adolescent centres known as kafe@TEEN to increase access to reproductive health information and services for young people aged 13 to 24 years.
 
 
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2011 (2)




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The 44th session of the Commission on Population and Development on agenda item 4: general debate on national experience in population matters: fertility, reproductive health and development, 11th April, 2011
Item Type: Country Statement
Author: 
National Population and Family Development Board, Malaysia,  and
Author: 
National Population and Family Development Board, Malaysia and
Editor: 
Year:  11/04/2011
Abstract:  Fertility among Malaysian women is declining faster than expected due to the increase in the average age at first marriage for women that has risen from 24.7 years in 1991 to 25.3 in 2004. Malaysia's total fertility rate (TFR) is expected to reach the replacement level by year 2015. With more and more women participating in the labour force and prioritising career development, this has also led to many highly educated women choosing to marry late or not to marry at all. Malaysia hopes to sustain the current fertility rate and not let it fall below replacement level. Sustaining the current TFR of 2.3 is one of the major challenges that has to be monitored as it can lead to contraction of labour supply, rapid aging of the population and other social implications.
 
 
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Cytotoxicity and expression profiles of apoptosis gene related in human cervical cancer (HeLa) cell lines in response to Newcastle disease virus (NDV) strains AF2240 And V4-UPM
Item Type: Thesis
Author: 
Mohd Yussof, Mohd Azizuddin and
Author: 
Editor: 
Year:  01/01/2011
Abstract:  In this study the cytotoxicity and expression profiles of apoptosis gene related in human cervical cancer (HeLa) cell lines in response to Newcastle disease virus (NDV) strains AF2240 and V4-UPM were studied. NDV is a strain of avian paramyxovirus. NDV has been classified into the order Mononegavirales, family Paramyxoviridae, subfamily Paramyxovirinae and genus Rubulavirus. NDV caused severe economic losses in the poultry industry worldwide. Several local strains of Newcastle disease virus were reported to induce cytolysis to the cancerous cell lines. Strain AF2240 is a heat resistant viscerotropic velogenic NDV and strain V4-UPM is a heat resistant lentogenic which has significant higher thermostabilities of infectivity and haemagglutination were reported cytolysis leukemic cells in vitro and has shown in vivo anti leukemic agents . In this study the cytotoxicity effects of strains of NDV AF2240 and V4-UPM towards HeLa cell were determined by using standard microtetrazolium assay (MTT). Cytotoxicity dose 50% (CD50) cells treated with different titre of NDV as haemagglutination units (HAU) as compared to the untreated cells was estimated at 72 hours post-infection. The CD50 values obtained were 0.95 HAU and 1.0 HAU for strains AF2240 and V4-UPM, respectively. No cytolytic effect was noted towards normal cells (3T3) was observed. Both strains were also observed to inhibit HeLa cell proliferation. Morphological observations also have been done under inverted light and fluorescence microscopes. Under the inverted light microscope, the HeLa cells treated with both strains showed apoptotic features such as cell shrinkage, cell blebbing and formation of apoptotic bodies. Morphological features of apoptosis were also observed by using the AO/PI staining method under the fluorescence microscope. The AO/PI staining demonstrated the occurrence of apoptosis which was characterised mainly by chromatin condensation, nuclear shrinkage and formation of apoptotic bodies. Evidently, both strains AF2240 and V4-UPM used in the study were found to induce cells towards apoptosis rather than necrosis. NDV strain AF2240 and strain V4-UPM was also caused genotoxic in HeLa cells after two hours treatment with CD10 and CD25 values by alkaline comet assay. Results showed that HeLa cells treated with NDV strains AF2240, V4-UPM and hydrogen peroxide gave different distribution of scores. The HeLa cells treated with hydrogen peroxide as a positive control gave more percentage at score 2, 3 and 4 for both cytotoxicity values compared to the HeLa cells treated with NDV for both strains. Observation in this study has proved the genotoxic potential of the NDV strains AF2240 and V4-UPM to induce DNA damage on HeLa cells as early as two hours following treatment at very low cytotoxicity dose (CD10 and CD25) values. Meanwhile, the cell cycle analyses of HeLa cells treated with local strains of NDV AF2240 or V4-UPM did not induce cell cycle arrest in any specific phase. Sub-G1 phase (apoptosis peak) was found in both treated cells with a very high percentage compared to untreated cells with a small percentage. The results indicate that, the percentages of apoptosis were significantly increased (p≤0.05) in the time-dependent manner in both NDV strains treated HeLa cells. The molecular mechanisms of apoptosis may depend on the NDV strain and cell type. Six apoptosis genes were selected in this study namely Casp8, TNF-α, Bcl2 and TRAIL which focused on extrinsic pathway of apoptosis, while the gene Bax was used as an indicator for intrinsic pathway triggered by cellular stress. Lastly Myc, oncogene was used as an indicator for cell growth. From this study, NDV strain AF2240 was identified as a highly induced death receptor pathway due to the upregulation of TNF gene and the downregulation of Bax gene. Whereas NDV strain V4-UPM triggered both pathways but through the extrinsic pathway due to the very high expression of the TNF gene. The TNF gene was highly expressed due to its location and function as a stimulator of the death receptor pathway. The Casp8 gene was activated and expressed in order to enter the execution-phase of cell death. The Bcl-2 gene was continuously observed because of its function as an apoptosis regulator. Surprisingly, no expression was detected by the TRAIL gene. NDV strain AF2240 was more effective than NDV strain V4-UPM as an apoptosis inducer. These gene expression results showed that the apoptosis occurred and lead to cell death.
 
 
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2010 (1)




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Kajian faktor-faktor penghalang wanita berkahwin menjalani ujian pap smear
Item Type: Research Report
Author: 
Lembaga Penduduk dan Pembangunan Keluarga Negara, Malaysia,  and
Author: 
Editor: 
Year:  00/00/2010
Abstract:  Cervical cancer is the second most dangerous threat to women that not only lead to a loss of pregnancy, but can even be life threatening. 12.9 percent of all cancer deaths among women are also due to this cancer. Unfortunately, 80% of women who are first diagnosed with cervical cancer are already at serious stage and cannot be treated properly even though cervical cancer screening programs such as Pap Smear have existed since 1943. Statistics released by the Ministry of Health Malaysia through the 2003 National Cancer Registry Report showed, even after the implementation of the Pap Smear program, the incidence rate of cervical cancer has increased where in 1990 the incidence rate was 13.3 per 100,000 women compared to 19.7 per 100,000 women in 2003. This illustrates that the Pap Smear program in Malaysia is not comprehensive and not practiced by those who need it which is women who have started sexual activity. Therefore, the National Population and Family Development Board (LPPKN) has conducted a study in relation to cervical cancer screening or Pap Smear test. This study aimed to provide information on sociodemographic characteristics and reproductive history, women’s awareness on pap screening tests, women’s risk perceptions of cervical cancer, women’s attitudes towards the importance of Pap Smear testing and prevalence of Pap Smear screening test practice. This cross -sectional study was conducted in the Klang Valley, Melaka, Perak and Terengganu using purposive sampling. The total sample was 1000 people. The study population consisted of once married women aged between 20-65 years. This includes married women, widows and widowers. The conditions for rejecting the sample are ineligible women, such as unmarried women, non-Malaysian citizens and women who have had cervical cancer. The collection of research data is through interviews based on the text of the questionnaire provided. Respondents will be interviewed by interviewers who have been trained to obtain accurate information. To achieve the objectives of the study, the analysis used is descriptive analysis, chi-square test and t test. Therefore, based on the analysis that has been conducted, the prevalence of female Pap Smear test is 55.2 percent. Respondents showed a positive attitude when asked about the importance of Pap Smear test compared to other examinations, many of whom thought that this test was very important (92.7 percent). Only 4.2 percent considered the Pap Smear test not important and there were a few who could not provide certainty about its importance (3.1 percent). Not many can measure the risk they are facing to get cervical cancer as 377 (41.5 percent) people are unaware of the cancer risk they are facing. However, there were a total of 276 (30.4 percent) women who were confident that they were not at risk at all. Only 7.7 percent received a high risk of this cancer, moderate risk (5.6 percent) and low risk (14.9 percent).
 
 
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2006 (2)




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Tingkah laku seks di kalangan warga 45 tahun dan ke atas
Item Type: Research Report
Author: 
Lembaga Penduduk dan Pembangunan Keluarga Negara, Malaysia,  and
Author: 
Editor: 
Year:  00/00/2006
Abstract:  An opinion survey on 'Sexual Behavior Among Citizens 45 Years and Above' which was first conducted by the Human Reproduction Division (BRM) was conducted in the Klang Valley area from February to June 2003. The 'Convenience Sampling' sampling method was used where respondents who meet certain criteria fill in the questionnaire themselves. A total of 473 respondents consisting of 50.1% Malays, Indians (26.6%) and Chinese (23.3%) where men (53.5%) outnumber than women (46.5%). The majority of respondents comprised the age group of 50-59 years (41.25%). From the 220 female respondents, only 7.3% took hormone replacement therapy. The results of the study found that the importance and satisfaction of sex decreases with age where it is more pronounced among women than men. The frequency of sexual intercourse is performed in the range of 4-8 times a month (46.3%). Although only 16.7% of respondents had sex-related problems, 70.9% of them did not know the source of help and treatment for their problems. Among those who received treatment, 56.4% chose to seek modern treatment. 55.7% of respondents with sexual problems have at least one chronic disease. A total of 85.6% disagreed and looked for another partner as a way out of sex -related problems. Expectations for better sex in the future are still high at 69.1%. In conclusion, for middle-aged and above despite the declining importance of sexual intercourse, their right to access to knowledge and services related to sexual problems needs to be addressed immediately, especially by medical practitioners, especially the Human Reproduction Division and LPPKN in general. A systematic and ‘gender-sensitive’ approach can help overcome the problem of family institutional breakdown and problems related to incest.
 
 
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1996 (1)




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The National Study on reproductive health and sexuality of adolescents in Malaysia 1994/1995
Item Type: Research Report
Author: 
National Population and Family Development Board, Malaysia,  and
Author: 
National Population and Family Development Board, Malaysia and
Editor: 
Year:  00/00/1996
Abstract:  The National Study on Reproductive Health and Sexuality of Adolescents in Malaysia was initiated with the aim of formulating a National Programme on Reproductive Health for Adolescents. The specific objectives of the study are: i. to establish the status of the knowledge, attitude and practice of adolescents with regard to sexual and reproductive health, ii. to identify the constraints that adolescents face in seeking information and service relating to sexual and reproductive health, iii. to obtain the participation of adolescents in the design and implementation of programmes and activities for their own welfare. The single most expected outcome of the Study on Reproductive Health and Sexuality of Adolescents in Malaysia is a Cabinet memorandum which will propose appropriate policy and programme changes for the promotion and maintenance of optimal reproductive health among Malaysian adolescents geared towards the year 2020. This Memorandum will serve as a vital national reference and benchmark for evaluating future trends and patterns. It will be the basis for the reorientation of values, attitudes and approaches for the management of sexuality and reproductive health of adolescents in the country.
 
 
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1990 (8)




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The detection of estrogen-dependent proteins in monkey oviductal fluid
Item Type: Article
Author: 
A., Paliwal and
V.P., Kamboj and
B., Malaviya and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  To detect hormone induced changes in oviductal fluid protein pattern, flushings obtained from ovariectomized untreated and estradiol or estradiol plus progesterone treated monkeys were analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis. Superimposed densitometric scans of coomassie blue and periodic acid Schiff's (PAS) stained electrophoretic patterns revealed that estradiol treatment results in the appearance of a new protein (130 K) with maximum carbohydrate content as compared to other proteins present in the luminal milieu. The concentration of 85 and 95 K proteins also increase significantly after estradiol treatment. However, progesterone supplementation in estradiol primed monkeys results in the disappearance of 85 and 95 K proteins and decreased the 130 K glycoprotein considerably. Thus while estrogen acts as an inducer,progesterone antagonizes its action in monkey fallopian tubes and inhibits the synthesis of proteins which may have a role in early reproductive events.
 
 
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A role for cholesterol synthesized de novo by human umbilical cord
Item Type: Article
Author: 
A, Loganath and
R., Gunasegaram and
K.L., Peh and
P.C.T., Chew and
S.S., Ratnam and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  We have previously shown that the human umbilical cord in-vitro possess the ability to synthesize isocaproic acid and presumbly pregnenolone from cholesterol. Here, we examined the ability of the cord to synthesize cholesterol from acetate. Homogenates of umbilical cord (36-41 weeks gestation)obtained following spontaneous vaginal delivery from uncomplicated pregnancies (age 22-31 years) were incubated with [2-14C] acetate. Using the reverse-isotope dilution procedure, cholesterol was isolated and characterized as [14C] cholesterol acetate. Confirmation of identity of newly synthesized cholesterol was obtained after recrystallisation with added non-radioactive cholesterol acetate as standard. The rate of 14C incorporation is small but definite. The results indicate that the homogenates of human term umbilical cord contain the enzymes responsible for the conversion of [2-14C] acetate to [14C] cholesterol. It is suggested that cholesterol synthesized de novo can serve as a percursor for progesterone synthesis in-vivo.
 
 
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Coagulation profile in women on low-dose oral contraceptive pills
Item Type: Article
Author: 
Ishak, Roshidah and
Hassan, Khalid and
Yusof, Baharum and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  A cross-sectional study looking at the coagulation system was carried out involving 175 women attending the National Population and Family Development Board's Clinic at the Maternity Clinic, General Hospital, Kuala Lumpur. Study subjects comprise of 50 combined low-dose estrogen/progesterone oral contraceptive (OC) pill users and 75 non-OC users, acting as controls. The subjects were on the pill for a period of one year or more. There were significant shortening of the prothrombin time (PT) and partial thromboplastin time (PTT) in the OC group as compared to the control group. However, the activities of factors II, V and VII assayed were not significantly different between the two groups, suggesting that the changes in the PT and PTT were not significant clinically. The effect of long term usage of combined low-dose OC pills does not seem to indicate changes in the coagulation profile of the women in our study.
 
 
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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Author: 
M.T.M., Ismail and
H.A., Wadood and
M., Azhar and
Arshat, Hamid and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
 
 
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1987 (10)




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In vitro maturation of immature human oocytes in culture medium containing follicular fluid
Item Type: Article
Author: 
Ali, Jaffar and
A.J., Halim and
Arshat, Hamid and
Author: 
Editor: 
Year:  00/06/1987
Abstract:  In clinical IVF programs often immature oocytes are retrieved. Under such circumstances, numerous workers have advocated the procedure of pre-incubation in insemination medium for 12-36 hours, prior to insemination to induce maturation. We describe here the supplementation of follicular fluid in insemination medium to induce maturation of immature oocytes. The culture characteristics of the insemination medium containing follicular fluid appears to be better than the insemination medium without follicular fluid. Previous reports suggest the presence of a meiosis-inducing substance in follicular fluid which could trigger the resumption of meiosis and hence contribute to oocyte maturation. Other factors in follicular fluids which are yet to be elucidated, may also contribute to oocyte maturation. It is concluded that superior culture characteristics can be obtained if immature oocytes are preincubated for 16-36 hours in insemination medium containing 50% follicular fluid.
 
 
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Paramedic insertion of intrauterine device in a Malaysian family planning clinic
Item Type: Article
Author: 
Kwa, Siew Kim and
Arshat, Hamid and
AbdulJalil, Abdul Halim and
Ang, Eng Suan and
Suhaimi, Ayub and
Author: 
Editor: 
Year:  00/06/1987
Abstract:  A retrospective study was carried out in a Malaysian urban family planning clinic to evaluate the effectiveness of the paramedic in intrauterine contraceptive device (IUD)insertion. Seventy-nine multiload Cu 250 insertions by trained senior nurse in 1983 were measured against 369 insertions by doctors. Follow-up was done by nurses. At the cut-off date on 31st October 1985, the case records were examined. It was found that there was no statistically significant difference in termination percentage due to IUD complications. The nurse's group had a significantly higher percentage of failure to follow-up and also removal for personal reasons. No significant difference between the 2 groups was shown for termination due to accidental pregnancy, bleeding and pain, expulsion and pelvic infections. Removal of IUD to plan for pregnancy is high in both groups. The results show that the trained paramedic can be just as effective as doctors for IUD insertion.
 
 
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A prospective study of the acceptability of today vaginal contraceptive sponge among Malaysian women
Item Type: Article
Author: 
M.T.M., Ismail and
A.J., Halim and
Arshat, Hamid and
Author: 
Editor: 
Year:  00/06/1987
Abstract:  Fifty volunteers were selected in a two month prospective study to evaluate the acceptability of the Today vaginal sponge contraceptive among Malaysian women. One participant developed allergic reaction to the sponge and was taken off at an early stage of the study. Fourty- nine participants completed one month follow-up.Thirteen subjects discontinued for various reasons which are related and not related to the sponge. The remaining 36 participants completed the study. Few side effects were observed among the sponge users who completed the trial. One subject complained that the Loop of the sponge hurt her husband's penis. Most of the women who are on the sponges claimed that sexual intercourse is no longer messy. Four subjects claimed that the sponges pontentiated sexual feeling to their male partners. The sponge is generally accepted by the study group, which suggest that the general impression 'Asian Women abhor any form of vaginal contraception' is not totally correct. It is suggested that the contraceptive efficacy of the sponge be evaluated among our women in the future.
 
 
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1983 (8)


1978 (2)


1977 (2)