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Results for Search : "610 Medicine & health"


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Seroprevalence and factors associated with chlamydia trachomatis Infection among subfertile couples attending local public subfertility clinic
Item Type: Thesis
Author: 
Nekmat, Nily waheeda and
Author: 
Editor: 
Year:  00/00/2020
Abstract:  Chlamydia trachomatis is one of the agents that cause the sexually transmitted infections called chlamydia. People practicing risky sexual behaviours such as having multiple sex partners, exercising sexual intercourse at an early age, and undergoing unprotected sexual intercourse (without condom) with casual partners, are at risk of getting Chlamydia trachomatis infection. One of the significant, long term implications of risky sexual behaviours and sexually transmitted infection is infertility problems. The objectives of this study are to determine the seroprevalence of Chlamydia trachomatis (CT) among subfertile couples (husband and wife) of The Lembaga Penduduk dan Pembangunan Keluarga Negara (LPPKN) Subfertility Clinic and the factors associated with it (i.e. socio-demographic, duration of marriage, infertility factor, knowledge, attitude, practice of risky sexual behaviour (RSB) and predictors of Chlamydia trachomatis infection). The study is a cross-sectional study involving 112 infertile couples who underwent fertility treatment at LPPKN Subfertility Clinic from February 2018 until February 2019. Sociodemographic factors, duration of marriage, infertility factor, knowledge, attitude and practice (KAP) of risky sexual behavior (RSB) variables were determined via self-administered questionnaire that includes close ended questions. Meanwhile, Chlamydia trachomatis antigen and antibody (CT IgG) were determined via Enzyme Linked Immunosorbent Assay (ELISA) and rapid visual immunoassay test kit. This approach is selected to detect past and current infections of Chlamydia trachomatis through antibody and antigen detection in the blood serum, endocervical swab and urine samples. The response rate of this study was 97.39%. Majority of the respondents were aged between 25-34 years old and dominated by Malay ethnicity. Half of the respondents were among those with tertiary level of education and working in the private sector. In term of duration of marriage, half of the samples were couples who have been married for 3-7 years with majority of them had primary infertility. The female factor was reported to be the most dominant, followed by the unexplained factor and male factor. The seroprevalence of Chlamydia trachomatis among subfertile couples was 22.1% with 14.7% in husbands and 17.9 %, was reported among wives. In terms of knowledge, the results showed that most couples had high level of knowledge about risky sexual behaviours with a score of more than the mean (> 6) for both husbands and wives. Meanwhile, each husband and wife group had positive attitude towards risky sexual behavior. Approximately, 35.7% of husbands and 12.5% of wives were engaged with risky sexual behavior while a higher percentage of premarital sex was reported among the husbands compared to the wives. The chi-square results showed no association between CT status and socio -demographic factors, marital status and knowledge of RSB among subfertile couples. A significant association was recorded between CT and practices of RSB among couples (p< 0.05) particularly among those with multiple sex partners and husbands who had premarital sex (p<0.05). However, the Binary Logistic Regression analysis showed that none of the selected variables were significant predictors of CT status among the couples (p> 0.05). This study has determined that the seroprevalence of Chlamydia trachomatis (22.1%) and practices of risky sexual behavior among subfertile couples were high. Even though the results have shown no association between the dependent and independent variables, our finding has given an evidence based detection of past infection of Chlamydia trachomatis among subfertile couples. The practice of RSB has interrelated risk of getting CT and its long term consequences particularly on women reproductive system. Since the awareness on CT among public is considered low, it is crucial to sensitize them about it to ensure early detection and prevention. Therefore, CT screening is strongly recommended to be integrated in fertility work up. treatment and be promoted among sexually active adolescents and those young in age.
 
 
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Effects of socio-demographic, lifestyle and environmental factors on semen quality of men attending the sub fertility clinic in National Population and Family Development Board
Item Type: Research Report
Author: 
National Population and Family Development Board, Malaysia,  and
Author: 
Editor: 
Year:  02/01/2017
Abstract:  Couples are considered infertile if they are unable to conceive after one year of regular unprotected sex. The impact of lifestyle and environment on human fertility may vary depending on aetiology, demographic characteristics, genetic variation and other factors. As used by previous researchers, semen parameters were used to measure male infertility. Therefore, a decrease in semen quality is considered as a major factor in male infertility (http://en.wikipedia.org/wiki/Semen_quality). Previous studies (Kidd et al.2001,Eskenazi et al.2003, de La Rochebrochard and Thonneau 2003) have found that older men tend to have lower semen quality than younger ones. Testicular hyperthermia (elevated temperature) also has been known to affect male fertility. Men who like taking hot baths or sit in a sedentary position for a long time are at risk of having infertility. The objectives of this study are to identify the relationship between socio-demographic profile, lifestyle and environmental factors and semen quality, and to identify risk factors of poor semen quality among men attending the National Population and Family Development Board's (NPFDB) Subfertility Clinic. This study was done in Andrology Laboratory, NPFDB. Five hundred men from couples having their first infertility consultation between September 2010 abd June 2011 were recruited. Each patient was required to register, deposit semen and fill in the quesstionnaire. Sperm concentration, morphology and motility from semen analysis were used to study the relationship between semen quality and independent variables. Reference limits used were 15 cells x 10'6/ml, 4% and 40 %, respectively (World Health Organization, 2010). For statistical analysis, descriptive statistic, t test and ANOVA were used; 0.05 alpha value was chosen. Results showed that one-third of the study population were between 26 to 30 years of age and another one third were aged between 31 to 35 years old; mean age was 33.2. majority were Malays (71.2%), resided in Selangor (64.3%) and professionals (41.6%). Semen quality showed a negative relationship (p<0.05) with age. Meanwhile, sperm motility varied significantly for different ethnic group. Chinese (57.75%) had the highest motile-sperm compared to Malays (53.44%) and Indians (46.60%). Among lifestyles variables, frequency of sexual intercourse had a posive relationship (p<0.05) with sperm motility, whilst sedentary position had negative relationship (p<0.05) with the latter. Regression analysis was used to predict the risk factors of poor semen quality. This study found that men above 30 years old were two times more likely to have low sperm motility than men in the twenties. Moreover, less frequent sexual activity between couples was more likely (p<0.05) to have abnormal sperm compared to those who had sexual intercourse more frequently. In conclusion, this study suggested that age over 30 years and infrequent sexual activity were the risk factors to lower semen quality. Even though not regarded as a risk factor, sedentary work position had a negative impact on sperm motility. These factors may affect male fertility and cause difficulty in conception. Public awareness through advocacy programs and talks on infertility and its risk factors should be carried out regularly. Public education should be carried out to advice men to practice a healthy lifestyle and work life balance. This study has shown encouraging results, and should be replicated in the general population in Malaysia
 
 
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