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Results for Search : "616 Diseases"
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Penyakit Jangkitan Seksual= Sexual Transmitted Diseases (STD)
Item Type: Scientific Poster
Editor:
Year: 00/07/2024
Abstract: This study examines the extent of knowledge, attitudes, and practices (KAP) about Sexually Transmitted Diseases (STDs) among married women aged between 15-49 years. The findings of the study show that the level of knowledge about Sexually Transmitted Diseases (STDs) among women is moderate. Awareness campaigns about STDs that are more widespread and targeted especially at high-risk groups should be continued in an effort to increase their knowledge and awareness of the risks of STDs.
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Family well being & the emergence of global pandemic
Item Type: Newsletter
Editor:
Year: 00/00/2021
Abstract: National Population and Family Development Board (NPFDB) has introduced a Family Well-Being Index (FWBI) to specifically measure the well-being of families in Malaysia. The third series of the FWBI was conducted in 2019, prior to pandemic which start hitting the globe at the end of year. The FWBI 2019 reached a new highest score of 7.72 out of a maximum scale of 10. Although the FWBI 2019 score is still at a moderate level, it has shown an increase of 0.39 points compared to previous 7.33 for FWBI 2016. The FWBI 2019 score is a reflection of the family well-being in the country before COVID-19 pandemic began. Since then, every aspect of our life have been aff¬ected and subsequently transform the way we work and doing things. In addition to hampering the economy, the pandemic has also impacting family institution as a whole.
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Cervical cancer
Item Type: Infographic
Editor:
Year: 00/05/2018
Abstract: This infographic describes information about cervical cancer. Cervical cancer is the no.3 most common cancer among Malaysian women. Almost all cervical cancers are caused by Human Papilloma Virus (HPV). The symptoms such as unusual bleeding, heavier periods and bleeding after menopause.
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Pedofilia: selamatkah anak-anak kita?
Item Type: Article
Editor:
Year: 00/05/2017
Abstract: Recently, we were shocked by a news that was very foreign to us. A British man has been convicted of molesting and sexually abusing children, including in Malaysia. The psychological disorder is called pedophilia, while the perpetrators of child sexual harassment are called pedophiles. A person who suffers from pedophilia, may also not be a pedophiles (for not committing any sexual behavior against children), but a pedophile turns out to be a person suffering from pedophilia.
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Stress buat lelaki jadi kurang subur?
Item Type: Article
Editor:
Year: 00/03/2017
Abstract: Fertility problems are now increasing from time to time around the world. According to the World Health Organization (WHO 2010), infertility can be rooted; 40% of male factors or and 40% of female factors and 20% are from unknown factors (idiopathy).
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Kajian bagi mengenalpasti faktor-faktor risiko kanser payudara yang berkaitan dengan gaya hidup dalam kalangan wanita melayu di Kuala Lumpur
Item Type: Thesis
Editor:
Year: 00/02/2016
Abstract: Breast cancer is the most common cancer that has affected women all over the world. The worldwide rates of breast cancer incidence and mortality show a drastic and alarming increase. Until today the cause of the disease has yet to be identified. However, evidences from extensive researches related to breast cancer found that there were several lifestyle factors and some biomedical factors of the women that are scientifically recognized to increase the risk for breast cancer. In Malaysia, recent data obtained from data obtained from the National Population and Family Development Board (NPFDB) shows the incidence rate of breast cancer among Malay women was
found to have increased drastically in the last 8 years. This study aimed to identify risk factors, especially those related to lifestyle that may increase the risk of breast cancer among Malay women in Kuala Lumpur. The study also examined the knowledge of breast cancer among informants. A total of twelve breast cancer survivors were
interviewed in depth to identify and explore aspects of past lifestyle and biomedical background that may likely to increase their risk of getting breast cancer. Results show that some lifestyle and biological risk factors seen likely to increase the risk of getting breast cancer; late age at first birth or has never given birth (nulliparity), has never
breastfed or short period of breastfed, obesity, physical inactivity, high frequency of red meat intake, less intake of vegetables and fruits, psychological stress, family history of breast cancer and radiation treatment to the chest or breast. The study also found that the majority of the informants had poor knowledge regarding breast cancer.
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National experience in population matters: adolescents and youth
Item Type: Newsletter
Editor:
Year: 00/00/2012
Abstract: Adequate and accurate sexual and reproductive health information helps young people to make informed and responsible decisions. Howewer, cultural and religious sensitivities within the communities remain one of the major challenges in implementing reproductive health education for young people. Parents are still uncomfortable talking about reproductive health matters with their children ,leaving their children dependent upon information from their peers or other sources like the internet. The Government of Malaysia takes cognisance of the increasing importance of the sexual and reproductive health needs of adolescents and youth in Malaysia. Hence, the Government of Malaysia has put in place various policies and programmes to handle the sexual and reproductive health needs of the adolescents and youths. One of the main initiatives is the Healthy Programme without AIDS for Youth (PROSTAR). The Government of Malaysia also has established six youth-friendly adolescent centres known as kafe@TEEN to increase access to reproductive health information and services for young people aged 13 to 24 years.
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Cytotoxicity and expression profiles of apoptosis gene related in human cervical cancer (HeLa) cell lines in response to Newcastle disease virus (NDV) strains AF2240 And V4-UPM
Item Type: Thesis
Editor:
Year: 01/01/2011
Abstract: In this study the cytotoxicity and expression profiles of apoptosis gene related in human cervical cancer (HeLa) cell lines in response to Newcastle disease virus (NDV) strains AF2240 and V4-UPM were studied. NDV is a strain of avian paramyxovirus. NDV has been classified into the order Mononegavirales, family Paramyxoviridae, subfamily Paramyxovirinae and genus Rubulavirus. NDV caused severe economic losses in the poultry industry worldwide. Several local strains of Newcastle disease virus were reported to induce cytolysis to the cancerous cell lines. Strain AF2240 is a heat resistant viscerotropic velogenic NDV and strain V4-UPM is a heat resistant lentogenic which has significant higher thermostabilities of infectivity and haemagglutination were reported cytolysis leukemic cells in vitro and has shown in vivo anti leukemic agents . In this study the cytotoxicity effects of strains of NDV AF2240 and V4-UPM towards HeLa cell were determined by using standard microtetrazolium assay (MTT). Cytotoxicity dose 50% (CD50) cells treated with different titre of NDV as haemagglutination units (HAU) as compared to the untreated cells was estimated at 72 hours post-infection. The CD50 values obtained were 0.95 HAU and 1.0 HAU for strains AF2240 and V4-UPM, respectively. No cytolytic effect was noted towards normal cells (3T3) was observed. Both strains were also observed to inhibit HeLa cell proliferation. Morphological observations also have been done under inverted light and fluorescence microscopes. Under the inverted light microscope, the HeLa cells treated with both strains showed apoptotic features such as cell shrinkage, cell blebbing and formation of apoptotic bodies. Morphological features of apoptosis were also observed by using the AO/PI staining method under the fluorescence microscope. The AO/PI staining demonstrated the occurrence of apoptosis which was characterised mainly by chromatin condensation, nuclear shrinkage and formation of apoptotic bodies. Evidently, both strains AF2240 and V4-UPM used in the study were found to induce cells towards apoptosis rather than necrosis. NDV strain AF2240 and strain V4-UPM was also caused genotoxic in HeLa cells after two hours treatment with CD10 and CD25 values by alkaline comet assay. Results showed that HeLa cells treated with NDV strains AF2240, V4-UPM and hydrogen peroxide gave different distribution of scores. The HeLa cells treated with hydrogen peroxide as a positive control gave more percentage at score 2, 3 and 4 for both cytotoxicity values compared to the HeLa cells treated with NDV for both strains. Observation in this study has proved the genotoxic potential of the NDV strains AF2240 and V4-UPM to induce DNA damage on HeLa cells as early as two hours following treatment at very low cytotoxicity dose (CD10 and CD25) values. Meanwhile, the cell cycle analyses of HeLa cells treated with local strains of NDV AF2240 or V4-UPM did not induce cell cycle arrest in any specific phase. Sub-G1 phase (apoptosis peak) was found in both treated cells with a very high percentage compared to untreated cells with a small percentage. The results indicate that, the percentages of apoptosis were significantly increased (p≤0.05) in the time-dependent manner in both NDV strains treated HeLa cells. The molecular mechanisms of apoptosis may depend on the NDV strain and cell type. Six apoptosis genes were selected in this study namely Casp8, TNF-α, Bcl2 and TRAIL which focused on extrinsic pathway of apoptosis, while the gene Bax was used as an indicator for intrinsic pathway triggered by cellular stress. Lastly Myc, oncogene was used as an indicator for cell growth. From this study, NDV strain AF2240 was identified as a highly induced death receptor pathway due to the upregulation of TNF gene and the downregulation of Bax gene. Whereas NDV strain V4-UPM triggered both pathways but through the extrinsic pathway due to the very high expression of the TNF gene. The TNF gene was highly expressed due to its location and function as a stimulator of the death receptor pathway. The Casp8 gene was activated and expressed in order to enter the execution-phase of cell death. The Bcl-2 gene was continuously observed because of its function as an apoptosis regulator. Surprisingly, no expression was detected by the TRAIL gene. NDV strain AF2240 was more effective than NDV strain V4-UPM as an apoptosis inducer. These gene expression results showed that the apoptosis occurred and lead to cell death.
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