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Effect of centchroman on lipid metabolism in genital organs of female rhesus monkeys (macaca mulatta)


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Item type Article
Subjects 600 Technology > 610 Medicine & health > 618 Gynecology, obstetrics, pediatrics & geriatrics
Division/Agency LPPKN - National Population and Family Development Board, Malaysia: Human Reproductive Division
Keywords Early embryonic development, Endogenous hormones, Lipid constituents
Additional Information The hard copy can be refer at Resource Centre, NPFDB.
Abstract Effect of Centchroman (3,4-trans-2, 2-dimenthyl-3-phenyl-4-p (B-pyrrolidinoethoxy)-phenyl-7-methoxy chroman)treatment at 1 and 2.5 mg/kg; for 3, 6 and 12 months on lipids constituents of uterus,cervix and vagina was studied. Centchroman did not cause any consistent pattern of alteration in lipid contents of uterus, cervix and vagina of female rhesus monkey. However, uterine phospholipids were decreased at both the doses and cervical and vaginal triglycerides increases at higher dose. The altered nature of responses in the genital organs may be due to manifestation of estrogenic-cum-antiestrogenic properties of centchroman.
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