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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
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Hemorrheology and fibrinolytic response in women taking oral contraceptive pills
Item Type: Article
Editor:
Year: 00/12/1987
Abstract: A study was conducted on a total of 107 women attending the National Population and Family Development Board, Malaysia (NPFDB) Maternity Hospital, Kuala Lumpur. The subjects were divided into 3 groups. Group I and II consisted of woman on a low-dose combined estrogen and progestagen pills for a duration of 3-6 months and 1-2 year respectively. Group III was a control group consisting of women not on pills. A series of tests to evaluate hemorrheology and the fibrinolytic response were carried out. The results obtained showed no definite or significant difference in the two systems for all the three groups investigated. These findings are comparable to those reported by other investigators, implying relative safety of these pills in the local population.
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A five-year review of diagnostic laparoscopy and female sterilizations in 52 centers in Malaysia
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: Doctors participating in the Laparoscopy Program of the National Population and Family Development Board, Malaysia return data on all cases of diagnostic laparoscopy and female sterilizations carried in their centres. Data on 2,179 cases of diagnostic laparoscopy and 4,740 cases of female sterilizations for the period 1981-1985 are analysed. States with the highest return rates are Kuala Lumpur Federal Territory, Negeri Sembilan, Johor and Perak. The Specialist Centre of the Board alone accounted for one-third of the cases. Data for female sterilizations are further analysed. Complication rates for laparoscopy and minilaparotomy techniques are low at between 0.5 to 2.5 per 100 procedures. All doctors providing such services should be encouraged to participate in this Program and submit data in order to improve and learn from this Program.
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In vitro maturation of immature human oocytes in culture medium containing follicular fluid
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: In clinical IVF programs often immature oocytes are retrieved. Under such circumstances, numerous workers have advocated the procedure of pre-incubation in insemination medium for 12-36 hours, prior to insemination to induce maturation. We describe here the supplementation of follicular fluid in insemination medium to induce maturation of immature oocytes. The culture characteristics of the insemination medium containing follicular fluid appears to be better than the insemination medium without follicular fluid. Previous reports suggest the presence of a meiosis-inducing substance in follicular fluid which could trigger the resumption of meiosis and hence contribute to oocyte maturation. Other factors in follicular fluids which are yet to be elucidated, may also contribute to oocyte maturation. It is concluded that superior culture characteristics can be obtained if immature oocytes are preincubated for 16-36 hours in insemination medium containing 50% follicular fluid.
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Maternal reciprocal translocation t(1p;6p) in a couple with recurrent spontaneous abortion
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: G-banded chromosome complements were analyzed from peripheral blood lymphocytes of a couple who had experinced for spontaneous abortions. The karyotype of the husband was designated as 46,XY, while the wife's karyotype was designated as 46,XX, t(1p;6p). Balanced reciprocal translocations appear to be associated with the recurrent spontaneous abortions experienced by the couple. We report here a case of a maternal (1p;6p) reciprocal translocation in a couple with repeated fetal loss.
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Paramedic insertion of intrauterine device in a Malaysian family planning clinic
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: A retrospective study was carried out in a Malaysian urban family planning clinic to evaluate the effectiveness of the paramedic in intrauterine contraceptive device (IUD)insertion. Seventy-nine multiload Cu 250 insertions by trained senior nurse in 1983 were measured against 369 insertions by doctors. Follow-up was done by nurses. At the cut-off date on 31st October 1985, the case records were examined. It was found that there was no statistically significant difference in termination percentage due to IUD complications. The nurse's group had a significantly higher percentage of failure to follow-up and also removal for personal reasons. No significant difference between the 2 groups was shown for termination due to accidental pregnancy, bleeding and pain, expulsion and pelvic infections. Removal of IUD to plan for pregnancy is high in both groups. The results show that the trained paramedic can be just as effective as doctors for IUD insertion.
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A prospective study of the acceptability of today vaginal contraceptive sponge among Malaysian women
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: Fifty volunteers were selected in a two month prospective study to evaluate the acceptability of the Today vaginal sponge contraceptive among Malaysian women. One participant developed allergic reaction to the sponge and was taken off at an early stage of the study. Fourty- nine participants completed one month follow-up.Thirteen subjects discontinued for various reasons which are related and not related to the sponge. The remaining 36 participants completed the study. Few side effects were observed among the sponge users who completed the trial. One subject complained that the Loop of the sponge hurt her husband's penis. Most of the women who are on the sponges claimed that sexual intercourse is no longer messy. Four subjects claimed that the sponges pontentiated sexual feeling to their male partners. The sponge is generally accepted by the study group, which suggest that the general impression 'Asian Women abhor any form of vaginal contraception' is not totally correct. It is suggested that the contraceptive efficacy of the sponge be evaluated among our women in the future.
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Office laparoscopic assessment of female fertility
Item Type: Article
Editor:
Year: 00/01/1983
Abstract: The preliminary report details our experience and also serves to evaluate the risk benefits of office laparoscopy for female fertility assessment in 183 subjects. The patients were admitted at about 8.00 in the morning and discharged at 3.00 to 4.00 in the afternoon after laparoscopy has been performed. Only 7.7 percent of the subjects required inhalational anesthetic gases along with a combination of intravenous sedation and local anesthetic infiltration. The pick-up rate for pelvic abnormality is fairly high, approximately 22.4 percent. Difficulties and complications encountered during laparoscopy were minimal and easily overcome.The benefits of laparoscopy overrules assessment and sterilization feature laparoscopy on an 'outpatient basis' as one of its main activities.
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Actinomyces-like organisms in the cervical smears of IUCD users
Item Type: Article
Editor:
Year: 00/01/1983
Abstract: Cervical smears of 128 intrauterine contraceptive device users were stained by Gram stain and screened for the presence of Actinomyces-like organisms. Actinomyces-like organisms were observed in 5.5 percent, pus cell in 20.1 percent and yeast cells in 10.2 percent of the smears examined. The average duration of insertion was 8 months. Smears of 103 controls were negative for Actinomyces-like organisms, pus cells were observed in 8.7 percent and yeasts in 4.8 percent.
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Female sterilization using filshie clip in private practice
Item Type: Article
Editor:
Year: 00/01/1983
Abstract: The findings of a trial clip female sterilization program in private practice in Malaysia is presented. The Filshie clips were successfully applied in 382 subjects. Complications encountered were minimal. Only one subject presented with an intrauterine pregnancy following sterilization (0.3 percent). The success rate was very high in the region of 99.7 percent. This study also strengthens the view that private practitioners can play a very important role in the delivery of family planning advice and services to the masses in developing countries.
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