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Kajian perbandingan penggunaan tiga jenis rawatan hormon FSH dalam kalangan pesakit subfertiliti yang menjalani prosedur permanian beradas di Lembaga Penduduk dan Pembangunan Keluarga Negara
Item Type: Research Report
Editor:
Year: 02/01/2017
Abstract: Since 1979, the National Population and Family Development Board (NPFDB) has been providing subfertility management services to the public especially middle-income group. In line with the rapid pace of the latest technology and research developments, there are various types of fertility drugs in the form of injections which had been used in subfertility treatment. The main function of this injection is to mature the follicles where the main hormone contained in this injection is the follicle stimulating hormone (Follicle Stimulating Hormone, FSH). In general, there are three types of FSH injections, which is a recombinant FSH (rFSH) that have 100 percent synthetic hormone, urinary FSH (uFSH) that derived from menopausal urine and highly purified urinary FSH (hp-uFSH) that also derived from menopausal urine but more pure state than uFSH. All three hormones have FSH’s activities but uFSH and hp-uFSH also have Luteinizing Hormone’s activity (LH). Thus, NPFDB has taken initiative to conduct a comparative study on the use of three types of FSH hormone treatment, namely Gonal F (rFSH), Folliova (uFSH) and Menopur (hp-uFSH), among subfertilitie’s patient who’s undergoing Intrauterine Insemination Technique (IUI). Among others, the three types of hormones were studied in terms of effevtivenee and cost burden. The study sample was from patients with unknown cause of subfertilitie’s problem and they visit NPFDB Subfertilitie’s Clinic, Headquarters, from June 2010 to May 2012. The sampling method was random. The patient and researcher do not know the treatment regimen to be initiated until a closed sample containing the treatment regimen code number is opened by the patient before starting treatment. Data were collected, recorded and anlyzed using Statistical Package for the Social Sciences (SPSS) software. Although originally a total of 90 female patients were targeted to be recruited into this study. 30 patients for each type of FSH hormone, but at the end of the study only 39 patients met all eligibility criteria and agreed to participate in this study. The result showed that average of the patients was 28.3 years and the majority were ethnic Malays (76.9%). Most of the patients had a household income between RM 5,000.00 and RM 10,000.00 (51.4%). The percentage of patients requiring more than three injections to procedure mature follicles was lowest for Folliova (41.7%), compared with Menopur (50.0%) and Gonal F (55.6%). Similarly in terms of the number of follicles produced, the Folliova regime (58.3%) produced more follicles (more than three follicles) than other regimes. A total of 16.7 percent of patients who took Menopur injections were confirmed pregnant, while no pregnany occurred among patients who took Folliova and Gonal F. In terms of cost, at the time of this study, the price of three 75IU injections was RM 334.20 for Gonal F, RM 187.20 for Folliova and RM 271.20 for Menopur. In conclusion, this study shows that, hp-uFSH (Menopur) gives the highest pregnancy rate compared to Gonal F and Folliova. Furthemore, the price of Menopur is moderate (affordable) for patients. Therefore, highly purified urinary FSH is a good gonadotropin choice for couples with unexplained subfertility undergoing an IUI procedure and it may be the main choice for patients who need a combination fertility pill stimulation regimen and gonadotropin injections. As a suggestion, such a study should be conducted with a larger sample size to obtain more significant results and be representative of actual population.
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Nuptiality, fertility and contraceptive use: preliminary findings from the 5th Malaysian Population and Family Survey (MPFS -5)
Item Type: Conference or Workshop Item
Editor:
Year: 00/00/2015
Abstract: The current marital trend status shows more than 90 % are currently married while the percentage of divorce or separation is increasing. Next, current marital status by age group in 2014 showed that 93.1 % is currently married and 5.3 % among women 20-24 are divorce or separated. This paper discuss about nuptiality, fertility and contraceptive use from preliminary finding of the Fifth Malaysian Population and Family Survey (MPFS-5) 2014.
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Future study- understanding the puzzling trend of high birth rate among contraceptive users in Malaysia: A case study from Malaysian Population and Family Survey, 2004
Item Type: Conference or Workshop Item
Editor:
Year: 00/00/2014
Abstract: In 1957-1966, Family Planning Association has pioneering the family planning services in most of the states of Malaysia. At that time, the family planning services were mostly available only in urban areas (NPFDB: Kuala Lumpur, Report on Malaysian Population and Family Survey, 1974). Family planning was first made as an official policy during the First Malaysia Plan in 1966, successfully through the National Planning Programme (NPP). The objectives of this study is to examine the fertility levels of respondents whose practiced family planning compared to that of who have never practiced it and this study also to study the link between socio-economic and cultural variables with those eight intermediate variables on fertility in Malaysia.
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Determinants of contraceptive behaviour among married women in Peninsular Malaysia
Item Type: Conference or Workshop Item
Editor:
Year: 00/00/2012
Abstract: Modelling the trends and patterns of contraceptive use have drawn great interests among researchers worldwide but the case is not so in Malaysia. This study models the relationship between contraceptive use and several socio-demographic factors that include age at first marriage, ethnic group, level of education, employment status, place of residence, and number of life birth, of married women in Malaysia. The objectives of this study are; to describe the trend of contraceptive behaviour according to socio-demographic factors that affect their decision in contraceptive practices and also to identify determinants of contraceptive use among married women in Malaysia. Based on the trend analysis, the study indicates that there is an increasing pattern of women delaying marriage. The general trend of contraceptive use also indicates that there have been changes in the behaviour of users according to selected socio-demographic characteristics across these surveys. Specifically, Malay women are more likely to practice family planning compared to Chinese and Indian women. The overall trend across ethnic group shows that Malay contraceptive users’ behaviour were in contrast with that of Chinese users in most aspects. Favourable contraceptive methods among Malaysian women were oral and traditional methods. Binary logistic regression was applied to identify the determinants of Malaysian women’s decision in birth control practice. Multinomial logistic regression was also applied to estimate the probability of favourable contraceptive method among these women in their contraceptive practice. Based on this study, it is found that among all selected socio-demographic characteristics, women’s employment had no significant effect on women’s decision in contraceptive practice and their choice of contraceptive method. This study has also discovered that women’s age, their age at first marriage, women’s desire to have more children, number of pregnancies, educational attainment, and ethnicity are determinants that significantly influence Malaysianwomen’s decision towards contraceptive practice and their choice of contraceptive method.
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