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TOPICS

Results for Topics : "Health"


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The National Study on reproductive health and sexuality of adolescents in Malaysia 1994/1995
Item Type: Research Report
Author: 
National Population and Family Development Board, Malaysia,  and
Author: 
National Population and Family Development Board, Malaysia and
Editor: 
Year:  00/00/1996
Abstract:  The National Study on Reproductive Health and Sexuality of Adolescents in Malaysia was initiated with the aim of formulating a National Programme on Reproductive Health for Adolescents. The specific objectives of the study are: i. to establish the status of the knowledge, attitude and practice of adolescents with regard to sexual and reproductive health, ii. to identify the constraints that adolescents face in seeking information and service relating to sexual and reproductive health, iii. to obtain the participation of adolescents in the design and implementation of programmes and activities for their own welfare. The single most expected outcome of the Study on Reproductive Health and Sexuality of Adolescents in Malaysia is a Cabinet memorandum which will propose appropriate policy and programme changes for the promotion and maintenance of optimal reproductive health among Malaysian adolescents geared towards the year 2020. This Memorandum will serve as a vital national reference and benchmark for evaluating future trends and patterns. It will be the basis for the reorientation of values, attitudes and approaches for the management of sexuality and reproductive health of adolescents in the country.
 
 
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A role for cholesterol synthesized de novo by human umbilical cord
Item Type: Article
Author: 
A, Loganath and
R., Gunasegaram and
K.L., Peh and
P.C.T., Chew and
S.S., Ratnam and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  We have previously shown that the human umbilical cord in-vitro possess the ability to synthesize isocaproic acid and presumbly pregnenolone from cholesterol. Here, we examined the ability of the cord to synthesize cholesterol from acetate. Homogenates of umbilical cord (36-41 weeks gestation)obtained following spontaneous vaginal delivery from uncomplicated pregnancies (age 22-31 years) were incubated with [2-14C] acetate. Using the reverse-isotope dilution procedure, cholesterol was isolated and characterized as [14C] cholesterol acetate. Confirmation of identity of newly synthesized cholesterol was obtained after recrystallisation with added non-radioactive cholesterol acetate as standard. The rate of 14C incorporation is small but definite. The results indicate that the homogenates of human term umbilical cord contain the enzymes responsible for the conversion of [2-14C] acetate to [14C] cholesterol. It is suggested that cholesterol synthesized de novo can serve as a percursor for progesterone synthesis in-vivo.
 
 
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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Author: 
M.T.M., Ismail and
H.A., Wadood and
M., Azhar and
Arshat, Hamid and
Author: 
Editor: 
Year:  00/12/1990
Abstract:  A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
 
 
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