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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
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A five-year review of diagnostic laparoscopy and female sterilizations in 52 centers in Malaysia
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: Doctors participating in the Laparoscopy Program of the National Population and Family Development Board, Malaysia return data on all cases of diagnostic laparoscopy and female sterilizations carried in their centres. Data on 2,179 cases of diagnostic laparoscopy and 4,740 cases of female sterilizations for the period 1981-1985 are analysed. States with the highest return rates are Kuala Lumpur Federal Territory, Negeri Sembilan, Johor and Perak. The Specialist Centre of the Board alone accounted for one-third of the cases. Data for female sterilizations are further analysed. Complication rates for laparoscopy and minilaparotomy techniques are low at between 0.5 to 2.5 per 100 procedures. All doctors providing such services should be encouraged to participate in this Program and submit data in order to improve and learn from this Program.
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In vitro maturation of immature human oocytes in culture medium containing follicular fluid
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: In clinical IVF programs often immature oocytes are retrieved. Under such circumstances, numerous workers have advocated the procedure of pre-incubation in insemination medium for 12-36 hours, prior to insemination to induce maturation. We describe here the supplementation of follicular fluid in insemination medium to induce maturation of immature oocytes. The culture characteristics of the insemination medium containing follicular fluid appears to be better than the insemination medium without follicular fluid. Previous reports suggest the presence of a meiosis-inducing substance in follicular fluid which could trigger the resumption of meiosis and hence contribute to oocyte maturation. Other factors in follicular fluids which are yet to be elucidated, may also contribute to oocyte maturation. It is concluded that superior culture characteristics can be obtained if immature oocytes are preincubated for 16-36 hours in insemination medium containing 50% follicular fluid.
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Malaysian Journal of Reproductive Health (Volume 1, Number 1, January 1983)
Item Type: Book
Editor:
Year: 00/01/1983
Abstract: An official publication of Reproductive Research Centre, National Family Planning Board, Malaysia, in collaboration with the Malaysian Association of maternal and Neonatal Health.
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Office laparoscopic assessment of female fertility
Item Type: Article
Editor:
Year: 00/01/1983
Abstract: The preliminary report details our experience and also serves to evaluate the risk benefits of office laparoscopy for female fertility assessment in 183 subjects. The patients were admitted at about 8.00 in the morning and discharged at 3.00 to 4.00 in the afternoon after laparoscopy has been performed. Only 7.7 percent of the subjects required inhalational anesthetic gases along with a combination of intravenous sedation and local anesthetic infiltration. The pick-up rate for pelvic abnormality is fairly high, approximately 22.4 percent. Difficulties and complications encountered during laparoscopy were minimal and easily overcome.The benefits of laparoscopy overrules assessment and sterilization feature laparoscopy on an 'outpatient basis' as one of its main activities.
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Problems of neonatal surgery in Malaysia
Item Type: Article
Editor:
Year: 00/01/1983
Abstract: From January 1970 to May 1981, there were 594 neonates admitted to the General Hospital, Kuala Lumpur for surgery. Three hundred and seventy-one cases bad major alimentary tract alimentary tract abnormalities 97.1 percent of which caused obstruction. High gut anomalies and diaphragmmatic hernia (Group A cases) were relatively uncommon and the overall post-operative mortality for this group was high (64.6 percent). Overall mortality declined from 75.0 percent in 1970 to 10.3 percent for the first six month of 1981. Death rate among the low birth weight infants and those with multiple anomalies however, remain high. Factors related to post-operative mortality are discussed. Foremost among them is the time of referral to the surgeon. Various problems of management in this hospital are also highlighted.
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Ethnicity, attitude and fertility survey
Item Type: Research Report
Editor:
Year: 00/00/1980
Abstract: The objectives of this study is to provide information of ethnic differentials in fertility and associated cultural practices in Malaysia, to test hypotheses explaining the differentials or linking the differentials to cultural practices and social structure and to assess the role of the fertility differentials in perceptions of ethnic relations.
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Malaysian Fertility and Family Survey - 1974
Item Type: Research Report
Editor:
Year: 00/04/1977
Abstract: The Malaysian Fertility and Family Survey (MFFS) embodies two major objectives, one international and one national. Internationally, the MFFS is part of the World fertility Survey (WFS) programme, aimed at studying human fertility and reproductive behaviour. Nationally it responds to the need for reliable data on the Knowledge, Attitudes and Practice (KAP) of family planning on which to base national planning of population programmes.
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