PUBLICATIONS
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Coagulation profile in women on low-dose oral contraceptive pills
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: A cross-sectional study looking at the coagulation system was carried out involving 175 women attending the National Population and Family Development Board's Clinic at the Maternity Clinic, General Hospital, Kuala Lumpur. Study subjects comprise of 50 combined low-dose estrogen/progesterone oral contraceptive (OC) pill users and 75 non-OC users, acting as controls. The subjects were on the pill for a period of one year or more. There were significant shortening of the prothrombin time (PT) and partial thromboplastin time (PTT) in the OC group as compared to the control group. However, the activities of factors II, V and VII assayed were not significantly different between the two groups, suggesting that the changes in the PT and PTT were not significant clinically. The effect of long term usage of combined low-dose OC pills does not seem to indicate changes in the coagulation profile of the women in our study.
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Comparative study on the acceptance and use of contraceptive methods in a rural population in Kelantan
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: The generally poor health indices for Kelantan and the strong cultural beliefs with reference to contraception dictated the need for this study. 350 women from neighbouring estates were studied via questionaires. It was found that only 44.85% use some form of contraception and 18.4% of these resorted to traditional methods. There was some relationship between race and choice of contraception. Education did play a role in encouraging contraception. Despite the low acceptance of contraception, spacing of children did exist-probably due to breastfeeding that's widely practised.
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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
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