PUBLICATIONS
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Clinical evaluation of Buserelin, a GnRH analogue in the management of moderate to severe pelvic endometriosis
Item Type: Article
Editor:
Year: 00/12/1990
Abstract: A local study, a part of a multinasional and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment of pelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. Baseline hormonal and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition, changes in symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels during the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved considerably. Buserelin was proven to be effective in the management of pelvic endometriosis and is well tolerated and safe.
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K.A.P. Study of Family planning among married Orang Asli Women of Hulu Langat District, Selangor Darul Ehsan, Malaysia
Item Type: Article
Editor:
Year: 00/00/1990
Abstract: A study of knowledge, attitude and practice was carried out among sixty nine married Orang Asli women in the district of Kuala Langat. The study showed that only a small proportion of the women were using family planning methods. About half of the study women were still uncertain with regards to their attitude towards family planning. The findings also showed that there was no diversity of the methods with oral contraceptive being the major choice. Majority of the husbands had indeed positive feeling towards family planning. The women also considered breastfeeding as a major method of contraception.
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Hemorrheology and fibrinolytic response in women taking oral contraceptive pills
Item Type: Article
Editor:
Year: 00/12/1987
Abstract: A study was conducted on a total of 107 women attending the National Population and Family Development Board, Malaysia (NPFDB) Maternity Hospital, Kuala Lumpur. The subjects were divided into 3 groups. Group I and II consisted of woman on a low-dose combined estrogen and progestagen pills for a duration of 3-6 months and 1-2 year respectively. Group III was a control group consisting of women not on pills. A series of tests to evaluate hemorrheology and the fibrinolytic response were carried out. The results obtained showed no definite or significant difference in the two systems for all the three groups investigated. These findings are comparable to those reported by other investigators, implying relative safety of these pills in the local population.
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A five-year review of diagnostic laparoscopy and female sterilizations in 52 centers in Malaysia
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: Doctors participating in the Laparoscopy Program of the National Population and Family Development Board, Malaysia return data on all cases of diagnostic laparoscopy and female sterilizations carried in their centres. Data on 2,179 cases of diagnostic laparoscopy and 4,740 cases of female sterilizations for the period 1981-1985 are analysed. States with the highest return rates are Kuala Lumpur Federal Territory, Negeri Sembilan, Johor and Perak. The Specialist Centre of the Board alone accounted for one-third of the cases. Data for female sterilizations are further analysed. Complication rates for laparoscopy and minilaparotomy techniques are low at between 0.5 to 2.5 per 100 procedures. All doctors providing such services should be encouraged to participate in this Program and submit data in order to improve and learn from this Program.
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In vitro maturation of immature human oocytes in culture medium containing follicular fluid
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: In clinical IVF programs often immature oocytes are retrieved. Under such circumstances, numerous workers have advocated the procedure of pre-incubation in insemination medium for 12-36 hours, prior to insemination to induce maturation. We describe here the supplementation of follicular fluid in insemination medium to induce maturation of immature oocytes. The culture characteristics of the insemination medium containing follicular fluid appears to be better than the insemination medium without follicular fluid. Previous reports suggest the presence of a meiosis-inducing substance in follicular fluid which could trigger the resumption of meiosis and hence contribute to oocyte maturation. Other factors in follicular fluids which are yet to be elucidated, may also contribute to oocyte maturation. It is concluded that superior culture characteristics can be obtained if immature oocytes are preincubated for 16-36 hours in insemination medium containing 50% follicular fluid.
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Maternal reciprocal translocation t(1p;6p) in a couple with recurrent spontaneous abortion
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: G-banded chromosome complements were analyzed from peripheral blood lymphocytes of a couple who had experinced for spontaneous abortions. The karyotype of the husband was designated as 46,XY, while the wife's karyotype was designated as 46,XX, t(1p;6p). Balanced reciprocal translocations appear to be associated with the recurrent spontaneous abortions experienced by the couple. We report here a case of a maternal (1p;6p) reciprocal translocation in a couple with repeated fetal loss.
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Paramedic insertion of intrauterine device in a Malaysian family planning clinic
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: A retrospective study was carried out in a Malaysian urban family planning clinic to evaluate the effectiveness of the paramedic in intrauterine contraceptive device (IUD)insertion. Seventy-nine multiload Cu 250 insertions by trained senior nurse in 1983 were measured against 369 insertions by doctors. Follow-up was done by nurses. At the cut-off date on 31st October 1985, the case records were examined. It was found that there was no statistically significant difference in termination percentage due to IUD complications. The nurse's group had a significantly higher percentage of failure to follow-up and also removal for personal reasons. No significant difference between the 2 groups was shown for termination due to accidental pregnancy, bleeding and pain, expulsion and pelvic infections. Removal of IUD to plan for pregnancy is high in both groups. The results show that the trained paramedic can be just as effective as doctors for IUD insertion.
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Effect of centchroman on lipid metabolism in genital organs of female rhesus monkeys (macaca mulatta)
Item Type: Article
Editor:
Year: 00/06/1987
Abstract: Effect of Centchroman (3,4-trans-2, 2-dimenthyl-3-phenyl-4-p (B-pyrrolidinoethoxy)-phenyl-7-methoxy chroman)treatment at 1 and 2.5 mg/kg; for 3, 6 and 12 months on lipids constituents of uterus,cervix and vagina was studied. Centchroman did not cause any consistent pattern of alteration in lipid contents of uterus, cervix and vagina of female rhesus monkey. However, uterine phospholipids were decreased at both the doses and cervical and vaginal triglycerides increases at higher dose. The altered nature of responses in the genital organs may be due to manifestation of estrogenic-cum-antiestrogenic properties of centchroman.
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